Identification and validation of a novel signature based on cell-cell communication in head and neck squamous cell carcinoma by integrated analysis of single-cell transcriptome and bulk RNA-sequencing

Identification and validation of a novel signature based on cell-cell communication in head and neck squamous cell carcinoma by integrated analysis of single-cell transcriptome and bulk RNA-sequencing

BackgroundThe heterogeneous crosstalk between tumor cells and other cells in their microenvironment means a notable difference in clinical outcomes of head and neck squamous cell carcinoma (HNSCC). CD8+ T cells and macrophages are effector factors of the immune system, which have direct killing and...

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Bibliographic Details
Main Authors: Jian Wang, Hong-Cun Sun, Cheng Cao, Jian-Dao Hu, Jing Qian, Tao Jiang, Wen-Bo Jiang, Shao Zhou, Xiao-Wen Qiu, Hong-Li Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
cell-cell communication
HNSCC
single-cell transcriptome analysis
CD8+ T cell
Tumor-associated macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1136729/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1136729/full

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