S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis

S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis

IntroductionSpondyloarthritis (SpA) is a common autoinflammatory disease. S100A8/ S100A9 alarmin is strongly expressed in the synovial sublining layers of psoriatic arthritis. S100A8/ S100A9 is the most abundant protein in rheumatoid arthritis synovial fluid (SF) and has a key role in promoting IL-6...

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Bibliographic Details
Main Authors: José L. Arias, Samanta C. Funes, Rodrigo Blas, Eduardo Callegari, Ricardo J. Eliçabe, María D. Páez, Alicia Munarriz, Rodolfo Pardo-Hidalgo, Héctor Tamashiro, María S. Di Genaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
S100A8
synovial fluid
fibroblast-like synoviocytes
IL-6
spondyloarthritis
MMP-9
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1077914/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1077914/full

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