A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart

A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart

The authors used 52 nonfailing and failing human hearts to develop a simple, high throughput left ventricular myocardial slice model that is stable by ATP and viability assays for at least 3 days. The model supports studies of signaling, contraction, and viral transduction. They use the model to sho...

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Bibliographic Details
Main Authors: R. Croft Thomas, Jr., MD, Abhishek Singh, MD, PhD, Patrick M. Cowley, PhD, Bat-Erdene Myagmar, MD, PhD, Megan D. Montgomery, PhD, Philip M. Swigart, BS, Teresa De Marco, MD, Anthony J. Baker, PhD, Paul C. Simpson, MD
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:JACC: Basic to Translational Science
Subjects:
alpha-1-adrenergic
cell signaling
human models
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000401

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http://www.sciencedirect.com/science/article/pii/S2452302X16000401

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