Dose Response of Acute ATP Supplementation on Strength Training Performance
Background: Chronic oral ATP supplementation benefits cardiovascular health, muscular performance, body composition, and recovery while attenuating muscle breakdown and fatigue. A single 400 mg dose of oral ATP supplementation improved lower body resistance training performance and energy expenditur...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Sports and Active Living |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fspor.2021.780459/full |
| _version_ | 1828956768361775104 |
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| author | Helton Pereira dos Santos Nunes de Moura Ralf Jäger Martin Purpura John A. Rathmacher John A. Rathmacher John C. Fuller Fabrício E. Rossi |
| author_facet | Helton Pereira dos Santos Nunes de Moura Ralf Jäger Martin Purpura John A. Rathmacher John A. Rathmacher John C. Fuller Fabrício E. Rossi |
| author_sort | Helton Pereira dos Santos Nunes de Moura |
| collection | DOAJ |
| description | Background: Chronic oral ATP supplementation benefits cardiovascular health, muscular performance, body composition, and recovery while attenuating muscle breakdown and fatigue. A single 400 mg dose of oral ATP supplementation improved lower body resistance training performance and energy expenditure in recreational resistance trained males, however, the minimal effective dose is currently unknown.Materials and Methods: Twenty recreationally trained men (age 28.6 ± 1.0 years, body mass 81.2 ± 2.0 kg, height 175.2 ± 1.4 cm, 1RM 141.5 ± 5.0 kg) consumed a single dose of either 400 mg, 200 mg, or 100 mg ATP (PEAK ATP®, TSI USA LLC, Missoula, MT, USA) or a placebo in a randomized, placebo-controlled crossover design, separated by a one week wash out between treatments. After warm-up, participants performed 4 sets of half-squats using free-weights until movement failure separated by 2 mins of rest between sets.Results: In comparison to placebo, 400 mg ATP significantly increased the number of set 1 repetitions (+13%, p = 0.04), and numerically increased total repetitions (+7%, p = 0.19) and total weight lifted (+6%, p = 0.22). 200 mg ATP numerically increased set 1 repetitions (+4% p = 0.47), while 100 mg ATP showed no improvements over placebo. 100 mg ATP (−4%, p < 0.05) and 400 mg ATP (−4%, p = 0.11) decreased the perceived rate of exertion compared to placebo.Conclusions: In this study, the effective minimal dose of acute oral ATP supplementation during resistance exercise to increase performance was determined to be 400 mg, while as little as 100 mg showed improvements in perceived exertion. |
| first_indexed | 2024-12-14T08:17:28Z |
| format | Article |
| id | doaj.art-a8f2bf092977470d81da73c1a43842e1 |
| institution | Directory Open Access Journal |
| issn | 2624-9367 |
| language | English |
| last_indexed | 2024-12-14T08:17:28Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sports and Active Living |
| spelling | doaj.art-a8f2bf092977470d81da73c1a43842e12022-12-21T23:09:53ZengFrontiers Media S.A.Frontiers in Sports and Active Living2624-93672021-12-01310.3389/fspor.2021.780459780459Dose Response of Acute ATP Supplementation on Strength Training PerformanceHelton Pereira dos Santos Nunes de Moura0Ralf Jäger1Martin Purpura2John A. Rathmacher3John A. Rathmacher4John C. Fuller5Fabrício E. Rossi6Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education and Postgraduate Program in Science and Health, Federal University of Piauí (UFPI), Teresina, BrazilIncrenovo LLC, Milwaukee, WI, United StatesIncrenovo LLC, Milwaukee, WI, United StatesMTI BioTech, Inc., Ames, IA, United StatesDepartment of Animal Science, Iowa State University, Ames, IA, United StatesTSI USA LLC, Missoula, MT, United StatesImmunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education and Postgraduate Program in Science and Health, Federal University of Piauí (UFPI), Teresina, BrazilBackground: Chronic oral ATP supplementation benefits cardiovascular health, muscular performance, body composition, and recovery while attenuating muscle breakdown and fatigue. A single 400 mg dose of oral ATP supplementation improved lower body resistance training performance and energy expenditure in recreational resistance trained males, however, the minimal effective dose is currently unknown.Materials and Methods: Twenty recreationally trained men (age 28.6 ± 1.0 years, body mass 81.2 ± 2.0 kg, height 175.2 ± 1.4 cm, 1RM 141.5 ± 5.0 kg) consumed a single dose of either 400 mg, 200 mg, or 100 mg ATP (PEAK ATP®, TSI USA LLC, Missoula, MT, USA) or a placebo in a randomized, placebo-controlled crossover design, separated by a one week wash out between treatments. After warm-up, participants performed 4 sets of half-squats using free-weights until movement failure separated by 2 mins of rest between sets.Results: In comparison to placebo, 400 mg ATP significantly increased the number of set 1 repetitions (+13%, p = 0.04), and numerically increased total repetitions (+7%, p = 0.19) and total weight lifted (+6%, p = 0.22). 200 mg ATP numerically increased set 1 repetitions (+4% p = 0.47), while 100 mg ATP showed no improvements over placebo. 100 mg ATP (−4%, p < 0.05) and 400 mg ATP (−4%, p = 0.11) decreased the perceived rate of exertion compared to placebo.Conclusions: In this study, the effective minimal dose of acute oral ATP supplementation during resistance exercise to increase performance was determined to be 400 mg, while as little as 100 mg showed improvements in perceived exertion.https://www.frontiersin.org/articles/10.3389/fspor.2021.780459/fullathletic performanceadenosine triphosphateresistance exerciseperceived exertionpre-workout nutrition |
| spellingShingle | Helton Pereira dos Santos Nunes de Moura Ralf Jäger Martin Purpura John A. Rathmacher John A. Rathmacher John C. Fuller Fabrício E. Rossi Dose Response of Acute ATP Supplementation on Strength Training Performance Frontiers in Sports and Active Living athletic performance adenosine triphosphate resistance exercise perceived exertion pre-workout nutrition |
| title | Dose Response of Acute ATP Supplementation on Strength Training Performance |
| title_full | Dose Response of Acute ATP Supplementation on Strength Training Performance |
| title_fullStr | Dose Response of Acute ATP Supplementation on Strength Training Performance |
| title_full_unstemmed | Dose Response of Acute ATP Supplementation on Strength Training Performance |
| title_short | Dose Response of Acute ATP Supplementation on Strength Training Performance |
| title_sort | dose response of acute atp supplementation on strength training performance |
| topic | athletic performance adenosine triphosphate resistance exercise perceived exertion pre-workout nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fspor.2021.780459/full |
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