The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recr...

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Main Authors: Laure N A Ries, Lakhansing Pardeshi, Zhiqiang Dong, Kaeling Tan, Jacob L Steenwyk, Ana Cristina Colabardini, Jaire A Ferreira Filho, Patricia A de Castro, Lilian P Silva, Nycolas W Preite, Fausto Almeida, Leandro J de Assis, Renato A C Dos Santos, Paul Bowyer, Michael Bromley, Rebecca A Owens, Sean Doyle, Marilene Demasi, Diego C R Hernández, Luís Eduardo S Netto, Monica T Pupo, Antonis Rokas, Flavio V Loures, Koon H Wong, Gustavo H Goldman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008645

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https://doi.org/10.1371/journal.ppat.1008645

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