O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

Abstract O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transferase (OGT) and O‑GlcNAcase (OGA). Whil...

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Bibliographic Details
Main Authors: Xiaohan Yan, Jingjing Zheng, Wenhao Ren, Shaoming Li, Shuying Yang, Keqian Zhi, Ling Gao
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Cell Communication and Signaling
Subjects:
Post-translational modification
O-GlcNAcylation
Bone pathophysiology
Online Access:https://doi.org/10.1186/s12964-024-01659-x

Internet

https://doi.org/10.1186/s12964-024-01659-x

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