Preclinical study for the ameliorating effect of l-ascorbic acid for the oxidative stress of chronic administration of organic nitrates on myocardial tissue in high sucrose/fat rat model

Preclinical study for the ameliorating effect of l-ascorbic acid for the oxidative stress of chronic administration of organic nitrates on myocardial tissue in high sucrose/fat rat model

Background: The therapeutic activity of Glyceryl trinitrate (GTN) is mainly regulated by liberating nitric oxide (NO) and reactive nitrogen species (RNS). During this biotransformation, oxidative stress and lipid peroxidation inside the red blood cells (RBCs) occur. Hemoglobin tightly binds to NO fo...

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Bibliographic Details
Main Authors: Ahmed Mohsen Elsaid Hamdan, Zuhair M. Mohammedsaleh, Aalaa Aboelnour, Sherif M.H. Elkannishy
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Saudi Pharmaceutical Journal
Subjects:
Methemoglobin
Organic nitrates
Oxidative stress
l-ascorbic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422001931

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http://www.sciencedirect.com/science/article/pii/S1319016422001931

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