Virtual Screening in the Identification of Sirtuins’ Activity Modulators

Virtual Screening in the Identification of Sirtuins’ Activity Modulators

Sirtuins are NAD<sup>+</sup>-dependent deac(et)ylases with different subcellular localization. The sirtuins’ family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins regulate a wide range...

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Bibliographic Details
Main Authors: Elena Abbotto, Naomi Scarano, Francesco Piacente, Enrico Millo, Elena Cichero, Santina Bruzzone
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
sirtuins
virtual screening
docking
rational design
activators
inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/17/5641

Internet

https://www.mdpi.com/1420-3049/27/17/5641

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