Structural Dynamics Behind Clinical Mutants of PncA-Asp12Ala, Pro54Leu, and His57Pro of Mycobacterium tuberculosis Associated With Pyrazinamide Resistance

Structural Dynamics Behind Clinical Mutants of PncA-Asp12Ala, Pro54Leu, and His57Pro of Mycobacterium tuberculosis Associated With Pyrazinamide Resistance

Pyrazinamide (PZA) is one of the main FDA approved drugs to be used as the first line of defense against Mycobacterium Tuberculosis (MTB). It is activated into pyrazinoic acid (POA) via MTB's pncA gene-encoded pyrazinamidase (PZase). Mutations are most commonly responsible for PZA-resistance in...

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Bibliographic Details
Main Authors: Aamir Mehmood, Muhammad Tahir Khan, Aman Chandra Kaushik, Anwar Sheed Khan, Muhammad Irfan, Dong-Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
drug resistance
simulation
mutations
PZA
MTB
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00404/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00404/full

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