Multiple Myeloma Derived Extracellular Vesicle Uptake by Monocyte Cells Stimulates IL-6 and MMP-9 Secretion and Promotes Cancer Cell Migration and Proliferation

Multiple Myeloma Derived Extracellular Vesicle Uptake by Monocyte Cells Stimulates IL-6 and MMP-9 Secretion and Promotes Cancer Cell Migration and Proliferation

Multiple Myeloma (MM) is an incurable haematological malignancy caused by uncontrolled growth of plasma cells. MM pathogenesis is attributed to crosstalk between plasma cells and the bone marrow microenvironment, where extracellular vesicles (EVs) play a role. In this study, EVs secreted from a pane...

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Bibliographic Details
Main Authors: Rebecca Sheridan, Kieran Brennan, Despina Bazou, Peter O’Gorman, David Matallanas, Margaret M. Mc Gee
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
cancer
extracellular vesicles
multiple myeloma
bone marrow microenvironment
metastasis
spliceosome
Online Access:https://www.mdpi.com/2072-6694/16/5/1011

Internet

https://www.mdpi.com/2072-6694/16/5/1011

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