Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism
Abstract The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporos...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02083-3 |
| _version_ | 1797233343309283328 |
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| author | Jinying Li Yongshao Chen Dingsheng Zha Chunhui Wu Xiaofen Li Li Yang Hui Cao Shexing Cai Yuebo Cai |
| author_facet | Jinying Li Yongshao Chen Dingsheng Zha Chunhui Wu Xiaofen Li Li Yang Hui Cao Shexing Cai Yuebo Cai |
| author_sort | Jinying Li |
| collection | DOAJ |
| description | Abstract The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporosis (OP). Mitigating ROS levels is a promising approach to counteracting OP. In this study, a nanozyme composed of magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered to effectively scavenge ROS and alleviate OP. The results of this study indicate that Mg-ZIF exhibits significant potential in scavenging ROS and effectively promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Additionally, Mg-ZIF was found to inhibit the differentiation of BMSCs into adipose cells. In vivo experiments further confirmed the ability of Mg-ZIF to mitigate OP by reducing ROS levels. Mechanistically, Mg-ZIF enhances the differentiation of BMSCs into osteoblasts by upregulating lipid metabolic pathways through ROS scavenging. The results indicate that Mg-ZIF has potential as an effective therapeutic approach for the treatment of osteoporosis. |
| first_indexed | 2024-04-24T16:14:40Z |
| format | Article |
| id | doaj.art-a9014bd77094462fa3492162eb465ec7 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-24T16:14:40Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a9014bd77094462fa3492162eb465ec72024-03-31T11:33:48ZengBMCLipids in Health and Disease1476-511X2024-03-0123111110.1186/s12944-024-02083-3Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolismJinying Li0Yongshao Chen1Dingsheng Zha2Chunhui Wu3Xiaofen Li4Li Yang5Hui Cao6Shexing Cai7Yuebo Cai8Department of Endocrinology, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityDepartment of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan UniversityAbstract The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporosis (OP). Mitigating ROS levels is a promising approach to counteracting OP. In this study, a nanozyme composed of magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered to effectively scavenge ROS and alleviate OP. The results of this study indicate that Mg-ZIF exhibits significant potential in scavenging ROS and effectively promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Additionally, Mg-ZIF was found to inhibit the differentiation of BMSCs into adipose cells. In vivo experiments further confirmed the ability of Mg-ZIF to mitigate OP by reducing ROS levels. Mechanistically, Mg-ZIF enhances the differentiation of BMSCs into osteoblasts by upregulating lipid metabolic pathways through ROS scavenging. The results indicate that Mg-ZIF has potential as an effective therapeutic approach for the treatment of osteoporosis.https://doi.org/10.1186/s12944-024-02083-3Mg-ZIF nanozymeOsteogenic differentiationLipid metabolismROSBMSCsOsteoporosis |
| spellingShingle | Jinying Li Yongshao Chen Dingsheng Zha Chunhui Wu Xiaofen Li Li Yang Hui Cao Shexing Cai Yuebo Cai Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism Lipids in Health and Disease Mg-ZIF nanozyme Osteogenic differentiation Lipid metabolism ROS BMSCs Osteoporosis |
| title | Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism |
| title_full | Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism |
| title_fullStr | Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism |
| title_full_unstemmed | Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism |
| title_short | Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism |
| title_sort | mg zif nanozyme regulates the switch between osteogenic and lipogenic differentiation in bmscs via lipid metabolism |
| topic | Mg-ZIF nanozyme Osteogenic differentiation Lipid metabolism ROS BMSCs Osteoporosis |
| url | https://doi.org/10.1186/s12944-024-02083-3 |
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