Hsp60 Chaperonin Acts as Barrier to Pharmacologically Induced Oxidative Stress Mediated Apoptosis in Tumor Cells with Differential stress Response

Mitochondrial functions play a central role in energy metabolism and provide survival fitness to both normal and tumor cells. Mitochondrial chaperonin Hsp60 is involved in both pro- and anti-apoptotic functions, but how Hsp60 senses the mitochondria selective oxidative stress response is unknown. In...

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Bibliographic Details
Main Authors: Upasana Sarangi, Manish Kumar Singh, Kanugovi Vijaya Vittal Abhijnya, Lebaka Prasanna Anjaneya Reddy, Badabagni Siva Prasad, Vikrant Vinay Pitke, Khanderao Paithankar, Amere Subbarao Sreedhar
Format: Article
Language:English
Published: AboutScience Srl 2013-01-01
Series:Drug Target Insights
Online Access:https://doi.org/10.4137/DTI.S12513