Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton

Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton

Spinosyns are natural broad-spectrum biological insecticides with a double glycosylated polyketide structure that are produced by aerobic fermentation of the actinomycete, Saccharopolyspora spinosa. However, their large-scale overproduction is hindered by poorly understood bottlenecks in optimizing...

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Bibliographic Details
Main Authors: Ziheng An, Hui Tao, Yong Wang, Bingqing Xia, Yang Zou, Shuai Fu, Fang Fang, Xiao Sun, Renqiong Huang, Yao Xia, Zixin Deng, Ran Liu, Tiangang Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Spinosyn
Spinosad
Polyketide
Polyketide synthase
Heterologous production
Streptomyces
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X2100051X

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http://www.sciencedirect.com/science/article/pii/S2405805X2100051X

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