Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine

Abstract Background The metabolic pathway of de novo lipogenesis (DNL) is upregulated in fatty liver disease and liver cancer. Inhibitors of DNL are in development for the treatment of these disorders; however, our previous study showed that blocking DNL unexpectedly exacerbated liver tumorigenesis...

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Bibliographic Details
Main Authors: Riya Shrestha, Calum S. Vancuylenburg, Martina Beretta, Mingyan Zhou, Divya P. Shah, Ellen M. Olzomer, Sian L. Richards, Kyle L. Hoehn, Frances L. Byrne
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cancer & Metabolism
Subjects:
Online Access:https://doi.org/10.1186/s40170-024-00363-1