Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease

Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease

Dyskinesia is a major side effect of chronic levodopa (L-DOPA) administration, the reference treatment for Parkinson's disease (PD). High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing L-DOPA req...

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Bibliographic Details
Main Authors: Adrien Quintana, Véronique Sgambato-Faure, Marc Savasta
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dyskinesia
6-OHDA lesion
L-DOPA
High-frequency stimulation
Glutamate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002240

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http://www.sciencedirect.com/science/article/pii/S0969996112002240

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