Genetic Circuits for Feedback Control of Gamma-Aminobutyric Acid Biosynthesis in Probiotic <i>Escherichia coli</i> Nissle 1917

Genetic Circuits for Feedback Control of Gamma-Aminobutyric Acid Biosynthesis in Probiotic <i>Escherichia coli</i> Nissle 1917

Engineered microorganisms such as the probiotic strain <i>Escherichia coli</i> Nissle 1917 (EcN) offer a strategy to sense and modulate the concentration of metabolites or therapeutics in the gastrointestinal tract. Here, we present an approach to regulate the production of the depressio...

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Bibliographic Details
Main Authors: Matthew Lebovich, Marcos A. Lora, Jared Gracia-David, Lauren B. Andrews
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Metabolites
Subjects:
genetically encoded biosensor
synthetic gene regulation
living therapeutic
gut microbial metabolites
depression
neurotransmitter
Online Access:https://www.mdpi.com/2218-1989/14/1/44

Internet

https://www.mdpi.com/2218-1989/14/1/44

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