Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice

Transcript-dependent effects of the CALCA gene on the progression of post-traumatic osteoarthritis in mice

Abstract Osteoarthritis represents a chronic degenerative joint disease with exceptional clinical relevance. Polymorphisms of the CALCA gene, giving rise to either a procalcitonin/calcitonin (PCT/CT) or a calcitonin gene-related peptide alpha (αCGRP) transcript by alternative splicing, were reported...

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Main Authors: Shan Jiang, Weixin Xie, Paul Richard Knapstein, Antonia Donat, Lilly-Charlotte Albertsen, Jan Sevecke, Cordula Erdmann, Jessika Appelt, Melanie Fuchs, Alexander Hildebrandt, Tazio Maleitzke, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05889-0

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https://doi.org/10.1038/s42003-024-05889-0

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