Conjugation with Tris Decreases the Risk of Ketoprofen-Induced Mucosal Damage and Reduces Inflammation-Associated Methane Production in a Rat Model of Colitis

Conjugation with Tris Decreases the Risk of Ketoprofen-Induced Mucosal Damage and Reduces Inflammation-Associated Methane Production in a Rat Model of Colitis

We have designed a new compound from the non-steroidal anti-inflammatory drug (NSAID) ketoprofen (Ket) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors, with the aim to reduce the gastrointestinal (GI) side effects of NSAID therapies. We investigated mucosal reactions in a standard ra...

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Bibliographic Details
Main Authors: Melinda Ugocsai, Anett Bársony, Réka Anna Varga, Ámos Gajda, Noémi Vida, Norbert Lajkó, Benedek Rónaszéki, Gábor Tóth, Mihály Boros, Dániel Érces, Gabriella Varga
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
non-steroid anti-inflammatory drugs
mucosa
microcirculation
inflammation
TNBS colitis
methane generation
Online Access:https://www.mdpi.com/1999-4923/15/9/2329

Internet

https://www.mdpi.com/1999-4923/15/9/2329

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