N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance

N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance

Graves’ ophthalmopathy (GO) obvious manifestation is the imbalance of Th17/Treg. N6-methyladenosine (m6A) methylation is an important regulator of Th17/Treg balance. However, few reports narrate how m6A regulators mediate the role of genes in GO progression. We explored the m6A modification of THBS1...

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Bibliographic Details
Main Authors: Lin-na Li, Jie-man Wu, Zong-ji Zheng, Shu-xian Li, Meng-yi Cai, Meng-chen Zou
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Autoimmunity
Subjects:
Graves’ ophthalmopathy
WTAP
THBS1
N6-methylation
glycolysis
PI3K-Akt signaling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/08916934.2024.2433628

Internet

https://www.tandfonline.com/doi/10.1080/08916934.2024.2433628

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