Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs

Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs

A major complication of hemophilia A therapy is the development of alloantibodies (inhibitors) that neutralize intravenously administered coagulation factor VIII (FVIII). Immune tolerance induction therapy (ITI) by repetitive FVIII injection can eradicate inhibitors, and thereby reduce morbidity and...

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Bibliographic Details
Main Authors: Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A. Schildberg, Paul A. Gleeson, Birgit M. Reipert, Johannes Oldenburg, Christian Kurts
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-11-01
Series:The Journal of Clinical Investigation
Subjects:
Hematology
Immunology
Online Access:https://doi.org/10.1172/JCI159925

Internet

https://doi.org/10.1172/JCI159925

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