Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors

Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors

Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivity to preproinsulin by CD4 T cells originally isol...

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Bibliographic Details
Main Authors: Laurie G. Landry, Amanda M. Anderson, Holger A. Russ, Liping Yu, Sally C. Kent, Mark A. Atkinson, Clayton E. Mathews, Aaron W. Michels, Maki Nakayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
antigens
type 1 diabetes
islets
T cell receptors
preproinsulin
epitopes
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.622647/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.622647/full

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