Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review
We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of pat...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Clinical Immunology Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772613423000240 |
| _version_ | 1797689213372596224 |
|---|---|
| author | G.I. Butel-Simoes C. Kiss K. Kong L.B. Rosen L.M. Hosking S. Barnes G.A. Jenkin S. Megaloudis B. Kumar S.M. Holland S. Ojaimi |
| author_facet | G.I. Butel-Simoes C. Kiss K. Kong L.B. Rosen L.M. Hosking S. Barnes G.A. Jenkin S. Megaloudis B. Kumar S.M. Holland S. Ojaimi |
| author_sort | G.I. Butel-Simoes |
| collection | DOAJ |
| description | We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of patient sera. A brief review of immunodeficiency caused by anti-IFNγ autoantibodies is also described. |
| first_indexed | 2024-03-12T01:42:41Z |
| format | Article |
| id | doaj.art-a91ebd7457b24cbf97d7a4e409addcbd |
| institution | Directory Open Access Journal |
| issn | 2772-6134 |
| language | English |
| last_indexed | 2024-03-12T01:42:41Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Immunology Communications |
| spelling | doaj.art-a91ebd7457b24cbf97d7a4e409addcbd2023-09-10T04:25:03ZengElsevierClinical Immunology Communications2772-61342023-12-0145559Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief reviewG.I. Butel-Simoes0C. Kiss1K. Kong2L.B. Rosen3L.M. Hosking4S. Barnes5G.A. Jenkin6S. Megaloudis7B. Kumar8S.M. Holland9S. Ojaimi10Monash Infectious Diseases, Monash Health, Victoria, AustraliaMonash Infectious Diseases, Monash Health, Victoria, AustraliaMonash Infectious Diseases, Monash Health, Victoria, AustraliaImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United StatesDepartment of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia; Immunology Laboratory, Laboratory Services, Royal Children's Hospital, Parkville, Victoria, AustraliaMonash Lung Sleep Allergy Immunology, Monash Health, Victoria, Australia; Monash University Department of Medicine, Monash University, Victoria, AustraliaMonash Infectious Diseases, Monash Health, Victoria, AustraliaHaematology Laboratory, Monash Pathology, Monash Health, Victoria, AustraliaAnatomical Pathology Laboratory, Monash Pathology, Monash Health, Victoria, AustraliaImmunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United StatesMonash Infectious Diseases, Monash Health, Victoria, Australia; Monash Lung Sleep Allergy Immunology, Monash Health, Victoria, Australia; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Victoria, Australia; Immunology Laboratory, Monash Pathology, Monash Health, Victoria, Australia; Corresponding author.We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of patient sera. A brief review of immunodeficiency caused by anti-IFNγ autoantibodies is also described.http://www.sciencedirect.com/science/article/pii/S2772613423000240Anti-interferon gamma autoantibodiesTuberculosisHaemophagocytic lymphohistiocytosis |
| spellingShingle | G.I. Butel-Simoes C. Kiss K. Kong L.B. Rosen L.M. Hosking S. Barnes G.A. Jenkin S. Megaloudis B. Kumar S.M. Holland S. Ojaimi Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review Clinical Immunology Communications Anti-interferon gamma autoantibodies Tuberculosis Haemophagocytic lymphohistiocytosis |
| title | Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review |
| title_full | Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review |
| title_fullStr | Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review |
| title_full_unstemmed | Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review |
| title_short | Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review |
| title_sort | disseminated tuberculosis cmv viraemia amp haemophagocytic lymphohistiocystosis syndrome in an adult patient with anti ifnγ autoantibodies case report and brief review |
| topic | Anti-interferon gamma autoantibodies Tuberculosis Haemophagocytic lymphohistiocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S2772613423000240 |
| work_keys_str_mv | AT gibutelsimoes disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT ckiss disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT kkong disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT lbrosen disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT lmhosking disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT sbarnes disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT gajenkin disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT smegaloudis disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT bkumar disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT smholland disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview AT sojaimi disseminatedtuberculosiscmvviraemiaamphaemophagocyticlymphohistiocystosissyndromeinanadultpatientwithantiifngautoantibodiescasereportandbriefreview |