Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultured human hepatocytes. RX-375 does not bind to AMPK...

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Bibliographic Details
Main Authors: Shuhei Kanagaki, Yusuke Tsutsui, Naoki Kobayashi, Takashi Komine, Minoru Ito, Yunike Akasaka, Michiaki Nagasawa, Tomohiro Ide, Naoki Omae, Kazuhisa Nakao, Makoto Rembutsu, Maki Iwago, Aki Yonezawa, Yusei Hosokawa, Tetsuya Hosooka, Wataru Ogawa, Koji Murakami
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Biochemistry
Small molecule
Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300370X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300370X

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