Early upregulation of cytosolic phospholipase A2α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis

Early upregulation of cytosolic phospholipase A2α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal multifactorial neurodegenerative disease characterized by the selective death of motor neurons. Cytosolic phospholipase A2 alpha (cPLA2α) upregulation and activation in the spinal cord of ALS patients has been reported. We have previ...

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Bibliographic Details
Main Authors: Yafa Fetfet Malada Edelstein, Yulia Solomonov, Nurit Hadad, Leenor Alfahel, Adrian Israelson, Rachel Levy
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Neuroinflammation
Subjects:
Cytosolic phospholipase A2α
ALS
Mutant SOD1G93A
Motor neurons
TNFα
Misfolded SOD1
Online Access:https://doi.org/10.1186/s12974-021-02326-5

Internet

https://doi.org/10.1186/s12974-021-02326-5

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