Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host

Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host

ABSTRACT Few studies have investigated host-bacterial interactions at sites of infection in humans using transcriptomics and metabolomics. Haemophilus ducreyi causes cutaneous ulcers in children and the genital ulcer disease chancroid in adults. We developed a human challenge model in which healthy...

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Bibliographic Details
Main Authors: Julie A. Brothwell, Kate R. Fortney, Hongyu Gao, Landon S. Wilson, Caroline F. Andrews, Tuan M. Tran, Xin Hu, Teresa A. Batteiger, Stephen Barnes, Yunlong Liu, Stanley M. Spinola
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
Haemophilus ducreyi
dual RNA-seq
metabolome
interactome
human
Online Access:https://journals.asm.org/doi/10.1128/mbio.03125-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03125-22

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