Development of Tofacitinib Loaded pH-Responsive Chitosan/Mucin Based Hydrogel Microparticles: In-Vitro Characterization and Toxicological Screening

Development of Tofacitinib Loaded pH-Responsive Chitosan/Mucin Based Hydrogel Microparticles: In-Vitro Characterization and Toxicological Screening

Tofacitinib is an antirheumatic drug characterized by a short half-life and poor permeability, which necessitates the development of sustained release formulation with enhanced permeability potential. To achieve this goal, the free radical polymerization technique was employed to develop mucin/chito...

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Bibliographic Details
Main Authors: Rania T. Malatani, Sana Bilal, Asif Mahmood, Rai Muhammad Sarfraz, Nadiah Zafar, Hira Ijaz, Umaira Rehman, Shehla Akbar, Hala M. Alkhalidi, Heba A. Gad
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Gels
Subjects:
tofacitinib
mucin
chitosan
arthritis
permeation
Online Access:https://www.mdpi.com/2310-2861/9/3/187

Internet

https://www.mdpi.com/2310-2861/9/3/187

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