Novel mechanisms of intestinal flora regulation in high-altitude hypoxia

Novel mechanisms of intestinal flora regulation in high-altitude hypoxia

Background: This study investigates the molecular mechanisms behind firmicutes-mediated macrophage (Mψ) polarization and glycolytic metabolic reprogramming through HIF-1α in response to intrinsic mucosal barrier injury induced by high-altitude hypoxia. Methods: Establishing a hypoxia mouse model of...

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Bibliographic Details
Main Authors: Fang Yan, Wen-qiang Yuan, Shi-min Wu, Yun-han Yang, De-jun Cui
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
High-altitude hypoxia
Firmicutes
Mψ polarization
Glycolysis
HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402414251X

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http://www.sciencedirect.com/science/article/pii/S240584402414251X

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