Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD<sup>+</sup> production. Despite the high efficacy of...

Full description

Bibliographic Details
Main Authors: Paulina Biniecka, Saki Matsumoto, Axel Belotti, Jessie Joussot, Jian Fei Bai, Somi Reddy Majjigapu, Paul Thoueille, Dany Spaggiari, Vincent Desfontaine, Francesco Piacente, Santina Bruzzone, Michele Cea, Laurent A. Decosterd, Pierre Vogel, Alessio Nencioni, Michel A. Duchosal, Aimable Nahimana
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
NAMPT inhibitor
NAD
anticancer
leukemia
lymphoma
multiple myeloma
Online Access:https://www.mdpi.com/1420-3049/28/4/1897

Internet

https://www.mdpi.com/1420-3049/28/4/1897

Similar Items