Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting

Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting

Introduction: In causal inference, the correct formulation of the scientific question of interest is a crucial step. The purpose of this study was to apply causal inference principles to external control analysis using observational data and illustrate the process to define the estimand attributes.M...

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Bibliographic Details
Main Authors: Letizia Polito, Qixing Liang, Navdeep Pal, Philani Mpofu, Ahmed Sawas, Olivier Humblet, Kaspar Rufibach, Dominik Heinzmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
causal inference
estimand framework
target trial emulation framework
external control
oncology
real-world data
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1223858/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1223858/full

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