Applying the estimand and target trial frameworks to external control analyses using observational data: a case study in the solid tumor setting
Introduction: In causal inference, the correct formulation of the scientific question of interest is a crucial step. The purpose of this study was to apply causal inference principles to external control analysis using observational data and illustrate the process to define the estimand attributes.M...
Main Authors: | Letizia Polito, Qixing Liang, Navdeep Pal, Philani Mpofu, Ahmed Sawas, Olivier Humblet, Kaspar Rufibach, Dominik Heinzmann |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2024-01-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1223858/full |
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