<i>Homo sapiens</i> May Incorporate Daily Acute Cycles of “Conditioning–Deconditioning” to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks and Circadian Rhythm Mediators

<i>Homo sapiens</i> May Incorporate Daily Acute Cycles of “Conditioning–Deconditioning” to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks and Circadian Rhythm Mediators

Human evolution required adaptation to the boundary conditions of Earth, including 1 g gravity. The bipedal mobility of <i>Homo sapiens</i> in that gravitational field causes ground reaction force (GRF) loading of their lower extremities, influencing the integrity of the tissues of those...

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Bibliographic Details
Main Authors: David A. Hart, Ronald F. Zernicke, Nigel G. Shrive
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
acute conditioning
acute deconditioning
myokines
osteokines
ground reaction forces
connective tissue homeostasis
Online Access:https://www.mdpi.com/1422-0067/23/17/9949

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https://www.mdpi.com/1422-0067/23/17/9949

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