Caffeine reduces oxidative stress to protect against hyperoxia-induced lung injury via the adenosine A2A receptor/cAMP/PKA/Src/ERK1/2/p38MAPK pathway

Caffeine reduces oxidative stress to protect against hyperoxia-induced lung injury via the adenosine A2A receptor/cAMP/PKA/Src/ERK1/2/p38MAPK pathway

Objectives: Caffeine has been shown to reduce the incidence of bronchopulmonary dysplasia (BPD). To investigate the protective mechanism of caffeine in a hyperoxia-based cell model of BPD in vitro.Methods: Type II alveolar epithelial cells (AECs II) were isolated and randomly divided into 6 groups:...

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Bibliographic Details
Main Authors: Xijuan Wang, Shuai Lv, Jianwei Sun, Meihui Zhang, Lei Zhang, Yan Sun, Ziyan Zhao, Dandan Wang, Xinjing Zhao, Jiajie Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Redox Report
Subjects:
Caffeine
apoptosis
A2AR
cAMP
PKA
ROS
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2022.2143114

Internet

https://www.tandfonline.com/doi/10.1080/13510002.2022.2143114

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