Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

Excessive Ca<sup>2+</sup> currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an emerging class of drugs in clinical use for major depressive disorder (MDD) and other neuropsychiatric diseases. The pharmaco...

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Bibliographic Details
Main Authors: Ezio Bettini, Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Jacopo Sgrignani, Corrado Carignani, Selena Nola, Patrizia Locatelli, Marco Pappagallo, Charles E. Inturrisi, Francesco Bifari, Andrea Cavalli, Andrea Alimonti, Luca Pani, Maurizio Fava, Sergio Traversa, Franco Folli, Paolo L. Manfredi
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
REL-1017
esmethadone HCL
N-methyl-D-aspartate receptor (NMDAR)
dextromethadone
d-methadone
ketamine
Online Access:https://www.mdpi.com/1424-8247/15/8/997

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https://www.mdpi.com/1424-8247/15/8/997

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