Synthesis, Biological Activity, and Molecular Modelling Studies of Naphthoquinone Derivatives as Promising Anticancer Candidates Targeting COX-2

Synthesis, Biological Activity, and Molecular Modelling Studies of Naphthoquinone Derivatives as Promising Anticancer Candidates Targeting COX-2

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-associated mortalities worldwide. Therefore, it is crucial to develop a novel therapeutic option targeting localized and metastatic NSCLC. In this paper, we describe the synthesis and biological activity characterization of naphtho...

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Bibliographic Details
Main Authors: Povilas Kavaliauskas, Felipe Stambuk Opazo, Waldo Acevedo, Ruta Petraitiene, Birutė Grybaitė, Kazimieras Anusevičius, Vytautas Mickevičius, Sergey Belyakov, Vidmantas Petraitis
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
non-small cell lung cancer
naphthoquinone
ROS
mitochondrial damage
anticancer
Online Access:https://www.mdpi.com/1424-8247/15/5/541

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https://www.mdpi.com/1424-8247/15/5/541

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