IFN-β Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation

IFN-β Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation

Cardiac fibroblasts (CFs) contribute to theinflammatory response to tissue damage, secreting both pro- and anti-inflammatory cytokines and chemokines. Interferon beta (IFN-β) induces the phosphorylation of signal transducer and activator of transcription (STAT) proteins through the activation of its...

Full description

Bibliographic Details
Main Authors: Samir Bolívar, Renatto Anfossi, Claudio Humeres, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jimenez, Francisco Olivares-Silva, Guillermo Díaz-Araya
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
IFN-β (interferon β)
cardiac fibroblast
STAT
proinflammatory
anti-infammatory
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01368/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01368/full

Similar Items