Differential H3K9me2 heterochromatin levels and concordant mRNA expression in postmortem brain tissue of individuals with schizophrenia, bipolar, and controls

The existence of repressive and durable chromatin assemblies along gene promoters or networks, especially in the brain, is of theoretical and therapeutic relevance in a subset of individuals diagnosed with schizophrenia who experience a chronic, persistent, and treatment-resistant trajectory. We use...

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Bibliographic Details
Main Authors: Hooriyah S. Rizavi, Kayla A. Chase, Chunyu Liu, Hannah Gavin, Cherise Rosen, Cuihua Xia, Alessandro Guidotti, Rajiv P. Sharma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1006109/full