Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation.

HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting its globular subdomains. It is compact when in solution but assumes an extended conformation when assembled within the immature HIV-1 virion. Here, we use molecular dynamics (MD) simulations to quantitatively...

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Bibliographic Details
Main Authors: Chen Lin, Paola Mendoza-Espinosa, Ioulia Rouzina, Orlando Guzmán, José Antonio Moreno-Razo, Joseph S Francisco, Robijn Bruinsma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221256