High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury

High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury

Abstract Background Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific therapeutics. Recently, mesenchymal stem cell (MSC) has been emerging as a promising cell-based therapy for IRI in t...

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Bibliographic Details
Main Authors: Shuo Wang, Songjie Cai, Weitao Zhang, Xigao Liu, Yan Li, Chao Zhang, Yigang Zeng, Ming Xu, Ruiming Rong, Tianshu Yang, Benkang Shi, Anil Chandraker, Cheng Yang, Tongyu Zhu
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Translational Medicine
Subjects:
Mesenchymal stem cell
HMGB1
Ischemia–reperfusion injury
Acute kidney injury
Cell therapy
Online Access:http://link.springer.com/article/10.1186/s12967-020-02334-8

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http://link.springer.com/article/10.1186/s12967-020-02334-8

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