Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

Abstract ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca2+ to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal isoform) and RyR2 using cryo-EM, and identifi...

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Bibliographic Details
Main Authors: Chris Lindsay, Mano Sitsapesan, Wei Mun Chan, Elisa Venturi, William Welch, Maria Musgaard, Rebecca Sitsapesan
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Scientific Reports
Subjects:
Ryanodine Binding
RyR Channels
Triphosphate Group
Predicted Binding Energy
Rotamer Toggle
Online Access:https://doi.org/10.1038/s41598-018-33328-8

Internet

https://doi.org/10.1038/s41598-018-33328-8

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