Role of pharmacogenetic factors in the development of side effects of methotrexate in the treatment of malignant tumors: A review

Role of pharmacogenetic factors in the development of side effects of methotrexate in the treatment of malignant tumors: A review

Methotrexate (MTX) is one of the main chemotherapeutic agents that has determined the high effectiveness of protocols for the treatment of acute lymphoblastic leukemia and non-Hodgkin lymphomas. The reverse side of the high anti-tumor activity of MTX is the adverse reactions, which require accompany...

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Bibliographic Details
Main Authors:	Timur T. Valiev, Vera V. Semenova, Anna Yu. Ikonnikova, Alisa A. Petrova, Tatiana S. Belysheva, Tatiana V. Nasedkina
Format:	Article
Language:	Russian
Published:	IP Habib O.N. 2021-12-01
Series:	Современная онкология
Subjects:	methotrexate pharmacogenetics genetic polymorphism folate cycle side effects
Online Access:	https://modernonco.orscience.ru/1815-1434/article/viewFile/79133/pdf

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