A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA damage response while promoting telomerase recruitm...

Full description

Bibliographic Details
Main Authors: Jonathan Strecker, Sonia Stinus, Mariana Pliego Caballero, Rachel K Szilard, Michael Chang, Daniel Durocher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
DNA double-stand breaks
Telomeres
Genome stability
Online Access:https://elifesciences.org/articles/23783

Internet

https://elifesciences.org/articles/23783

Similar Items