The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia

The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia

Hematopoietic stem cells (HSC) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDK) and cyclin proteins is critical for the maintenance of HSC homeostasis. Here, we found that the E3 ligase, TRIM31, regulates HSC homeostasis and...

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Detalles Bibliográficos
Autores principales: Kai Zhang, Dingdong Liu, Yafei Li, Zhencan Shi, Jun Guo, Chengjiang Gao, Hu Wang, Zhenyu Ju, Daojun Diao
Formato: Artículo
Lenguaje:English
Publicado: Ferrata Storti Foundation 2023-01-01
Colección:Haematologica
Acceso en línea:https://haematologica.org/article/view/10935

Internet

https://haematologica.org/article/view/10935

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