Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire+ mTEChi. However, it remains unknown whether thym...

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Bibliographic Details
Main Authors: Noella Lopes, Nicolas Boucherit, Jérémy C Santamaria, Nathan Provin, Jonathan Charaix, Pierre Ferrier, Matthieu Giraud, Magali Irla
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
thymus
tolerance
medullary thymic epithelial cells
cellular crosstalk
T cells
Online Access:https://elifesciences.org/articles/69982

Internet

https://elifesciences.org/articles/69982

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