Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway

Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway

Abstract Autophagy and cytoskeleton integrity of chondrocytes are a considered as major factors in the progression of osteoarthritis (OA) involving excessive chondrocyte apoptosis and senescence. Nesfatin-1, an adipokine, has been reported to be closely related to cell autophagy and cytoskeleton mal...

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Bibliographic Details
Main Authors: Lifeng Jiang, Safwat Adel Abdo Moqbel, Junxiong Zhu, Qiangchang Fu, Jiabin Lai, Changjian Lin, Lidong Wu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Nesfatin-1
Osteoarthritis
Autophagy
Cytoskeleton
RhoA/ROCK
Online Access:https://doi.org/10.1186/s13018-023-03539-5

Internet

https://doi.org/10.1186/s13018-023-03539-5

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