mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells

Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation, and metabolic failure in the retinal pigment epithe...

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Bibliographic Details
Main Authors: David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
retinal pigment epithelium (RPE) cells
age-related macular degeneration (AMD)
complement factor H (<i>CFH</i>/FH)
mammalian target of rapamycin (mTOR)
mitochondrial respiration
interactome
Online Access:https://www.mdpi.com/2076-3921/10/12/1944

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https://www.mdpi.com/2076-3921/10/12/1944

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