A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy
The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta. Using PubMed<sup>®</sup>, a systematic search was conducted to identify literature rele...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/11/2624 |
| _version_ | 1827639002628358144 |
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| author | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola |
| author_facet | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola |
| author_sort | Christine Gong |
| collection | DOAJ |
| description | The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta. Using PubMed<sup>®</sup>, a systematic search was conducted to identify literature relevant to drug metabolism and transport in pregnancy. PubMed was searched with pre-specified terms during the period of 26 May 2023 to 10 July 2023. The final dataset of 142 manuscripts was evaluated for evidence regarding the effect of gestational age and hormonal regulation on the expression of phase II enzymes (<i>n</i> = 16) and drug transporters (<i>n</i> = 38) in the pregnant woman and in the placenta. This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter localization, expression, and regulation during pregnancy, which emphasizes the need for further research. Moreover, the information collected in this review regarding phase II drug-metabolizing enzyme and drug transporter changes will aid in optimizing pregnancy physiologically based pharmacokinetic (PBPK) models to inform dose selection in the pregnant population. |
| first_indexed | 2024-03-09T16:31:39Z |
| format | Article |
| id | doaj.art-a96c35c23eea4e178c7fec153ecf8106 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T16:31:39Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a96c35c23eea4e178c7fec153ecf81062023-11-24T15:01:10ZengMDPI AGPharmaceutics1999-49232023-11-011511262410.3390/pharmaceutics15112624A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during PregnancyChristine Gong0Lynn N. Bertagnolli1David W. Boulton2Paola Coppola3School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USAAstraZeneca LP, Biopharmaceuticals R&D, Clinical Pharmacology & Safety Sciences, Clinical Pharmacology & Quantitative Pharmacology, Gaithersburg, MD 20878, USAAstraZeneca LP, Biopharmaceuticals R&D, Clinical Pharmacology & Safety Sciences, Clinical Pharmacology & Quantitative Pharmacology, Gaithersburg, MD 20878, USAAstraZeneca LP, Biopharmaceuticals R&D, Clinical Pharmacology & Safety Sciences, Clinical Pharmacology & Quantitative Pharmacology, Cambridge CB2 0AA, UKThe purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta. Using PubMed<sup>®</sup>, a systematic search was conducted to identify literature relevant to drug metabolism and transport in pregnancy. PubMed was searched with pre-specified terms during the period of 26 May 2023 to 10 July 2023. The final dataset of 142 manuscripts was evaluated for evidence regarding the effect of gestational age and hormonal regulation on the expression of phase II enzymes (<i>n</i> = 16) and drug transporters (<i>n</i> = 38) in the pregnant woman and in the placenta. This comprehensive review exposes gaps in current knowledge of phase II enzyme and drug transporter localization, expression, and regulation during pregnancy, which emphasizes the need for further research. Moreover, the information collected in this review regarding phase II drug-metabolizing enzyme and drug transporter changes will aid in optimizing pregnancy physiologically based pharmacokinetic (PBPK) models to inform dose selection in the pregnant population.https://www.mdpi.com/1999-4923/15/11/2624pregnancyplacentagestational changephase II enzymedrug transporterphysiologically based pharmacokinetic (PBPK) modeling |
| spellingShingle | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy Pharmaceutics pregnancy placenta gestational change phase II enzyme drug transporter physiologically based pharmacokinetic (PBPK) modeling |
| title | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy |
| title_full | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy |
| title_fullStr | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy |
| title_full_unstemmed | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy |
| title_short | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy |
| title_sort | literature review of changes in phase ii drug metabolizing enzyme and drug transporter expression during pregnancy |
| topic | pregnancy placenta gestational change phase II enzyme drug transporter physiologically based pharmacokinetic (PBPK) modeling |
| url | https://www.mdpi.com/1999-4923/15/11/2624 |
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