Mutation of Phenylalanine 23 of Newcastle Disease Virus Matrix Protein Inhibits Virus Release by Disrupting the Interaction between the FPIV L-Domain and Charged Multivesicular Body Protein 4B

Mutation of Phenylalanine 23 of Newcastle Disease Virus Matrix Protein Inhibits Virus Release by Disrupting the Interaction between the FPIV L-Domain and Charged Multivesicular Body Protein 4B

ABSTRACT The matrix (M) protein FPIV L-domain is conserved among multiple paramyxoviruses; however, its function and the associated mechanism remain unclear. In this study, the paramyxovirus Newcastle disease virus (NDV) was employed to study the FPIV L-domain. Two recombinant NDV strains, each carr...

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Bibliographic Details
Main Authors: Yu Pei, Jia Xue, Qingyuan Teng, Delan Feng, Min Huang, Rong Liang, Xiao Li, Ye Zhao, Jing Zhao, Guozhong Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Newcastle disease virus
M protein
FPIV L-domain
virus release
ESCRT machinery
CHMP4B
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04116-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04116-22

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