Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. Developing drugs that selectively reduce heart rate...

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Bibliographic Details
Main Authors: Viviana Delgado-Betancourt, Kroekkiat Chinda, Pietro Mesirca, Christian Barrère, Aurélie Covinhes, Laura Gallot, Anne Vincent, Isabelle Bidaud, Sarawut Kumphune, Joël Nargeot, Christophe Piot, Kevin Wickman, Matteo Elia Mangoni, Stéphanie Barrère-Lemaire
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart rate
myocardial infarction
cardioprotection
ischemia-reperfusion injury
heart rate reduction
cav1.3 calcium channel
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134503/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134503/full

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