Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma

Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in Asia; however, the molecular mechanism in its tumorigenesis remains unclear. Abnormal expression of claudins (CLDNs), a family of tight junction (TJ) proteins, plays an important role in the metastatic...

Full description

Bibliographic Details
Main Authors: Lemeng Sun, Liangshu Feng, Jiuwei Cui
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Diagnostic Pathology
Subjects:
Hepatocytes
Tight junction
Migration
CLDN17
Tyrosine kinase 2
Signal transducer and activator of transcription 3
Online Access:http://link.springer.com/article/10.1186/s13000-018-0749-1

Internet

http://link.springer.com/article/10.1186/s13000-018-0749-1

Similar Items