Downregulation of transposable elements extends lifespan in Caenorhabditis elegans

Downregulation of transposable elements extends lifespan in Caenorhabditis elegans

Abstract Mobility of transposable elements (TEs) frequently leads to insertional mutations in functional DNA regions. In the potentially immortal germline, TEs are effectively suppressed by the Piwi-piRNA pathway. However, in the genomes of ageing somatic cells lacking the effects of the pathway, TE...

Full description

Bibliographic Details
Main Authors: Ádám Sturm, Éva Saskői, Bernadette Hotzi, Anna Tarnóci, János Barna, Ferenc Bodnár, Himani Sharma, Tibor Kovács, Eszter Ari, Nóra Weinhardt, Csaba Kerepesi, András Perczel, Zoltán Ivics, Tibor Vellai
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40957-9

Internet

https://doi.org/10.1038/s41467-023-40957-9

Similar Items